Rather than featuring the typical 'bromance' storyline, 'Partners' will see Mark line up alongside a female partner.
The story involves the Hollywood star playing an LAPD detective who falls for a beautiful woman following a one-night stand.
Subsequently, however, it's revealed she is an FBI agent and also his new boss on a high profile case.
This comes shortly after Mark revealed he initially turned down the opportunity to star in 'Ted', admitting the idea for the film about a talking teddy bear sounded "absurd" when he first heard about it.
Mark said: "When you hear about ('Ted') for the first time, it sounds absurd. There's no good way to pitch it. It's ridiculous. So, I was like, 'Absolutely not!' It was one of those things where I was getting pressure from every angle.
"And then, when I talked to another agent about another project that I was producing and looking at one of their clients, they were like, 'I heard you're doing Ted.' I was like, 'What is this thing?'"